Number of the records: 1

botulotoxiny

Topical term	botulotoxiny
See link	botulin (UF)
	Botulin (UF)
	Botulinum Neurotoxin (UF)
	Botulinum Neurotoxins (UF)
	Botulinum Toxin (UF)
	Clostridium botulinum Toxins (UF)
	jed klobásový (UF)
	klobásový jed (UF)
See also	bakteriální proteiny
	bakteriální toxiny
	metaloendopeptidasy
	botulotoxiny typ A
	botulismus (RT)
	inhibitory uvolňování acetylcholinu (PA)
	neurotoxiny (PA)
Linking entry	Botulinum Toxins
Conspect	D08. - 811. - 277. - 656. - 300. - 480. - 153
	D08. - 811. - 277. - 656. - 675. - 374. - 153
	D12. - 776. - 097. - 156
	D23. - 946. - 123. - 179
Note	Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Database	MESH
References	(7) - MESH
	(1) - Books

subject heading

Number of the records: 1