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NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING
Title statement NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING [rukopis] / Zsófia Turi Additional Variant Titles NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING Personal name Turi, Zsófia, (dissertant) Translated title NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING Issue data 2019 Note Oponent Jan Bouchal Ved. práce Pavel Moudrý Oponent Pavla Vašicová Another responsib. Bouchal, Jan (opponent) Moudrý, Pavel, (školitel) Vašicová, Pavla, (opponent) Another responsib. Univerzita Palackého. Doktorské studijní programy LF (degree grantor) Keywords Ribosome biogenesis * nucleolus * HEATR1 * p53 * cancer * DNA damage response * Ribosome biogenesis * nucleolus * HEATR1 * p53 * cancer * DNA damage response Form, Genre disertace dissertations UDC (043.3) Country Česko Language čeština Document kind PUBLIKAČNÍ ČINNOST Title Ph.D. Degree program Doktorský Degree program Pediatrie Degreee discipline Pediatrie book
Kvalifikační práce Downloaded Size datum zpřístupnění 00263220-745516278.pdf 36 14.3 MB 30.04.2019 Posudek Typ posudku 00263220-opon-677998166.pdf Posudek oponenta Průběh obhajoby datum zadání datum odevzdání datum obhajoby přidělená hodnocení typ hodnocení 00263220-prubeh-803132754.pdf 28.08.2014 30.04.2019 26.11.2019 S 2
In this work, we identified a nucleolar protein, HEATR1 as an important player of ribosome biogenesis. In the absence of this protein, ribosome biogenesis stress is activated, characterized by the elevated level of p53, cell cycle arrest and structural changes of the nucleolus. Furthermore, HEATR1 seems to be involved in the early steps of ribosome biogenesis, since it possesses similar localization signal to Pol I and its ablation completely abolishes rRNA transcription. Besides its function in ribosome biosynthesis, HEATR1 may be required for DNA damage signaling as well, evidenced by DNA damage-dependent phosphorylation of this protein. Overall, our work presents HEATR1, a novel player in ribosome biogenesis and DNA damage response.In this work, we identified a nucleolar protein, HEATR1 as an important player of ribosome biogenesis. In the absence of this protein, ribosome biogenesis stress is activated, characterized by the elevated level of p53, cell cycle arrest and structural changes of the nucleolus. Furthermore, HEATR1 seems to be involved in the early steps of ribosome biogenesis, since it possesses similar localization signal to Pol I and its ablation completely abolishes rRNA transcription. Besides its function in ribosome biosynthesis, HEATR1 may be required for DNA damage signaling as well, evidenced by DNA damage-dependent phosphorylation of this protein. Overall, our work presents HEATR1, a novel player in ribosome biogenesis and DNA damage response.
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