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Effects of plant hormones on the lifespan of Caenorhabditis elegans

  1. Title statementEffects of plant hormones on the lifespan of Caenorhabditis elegans [rukopis] / Alena Kadlecová
    Additional Variant TitlesStudium vlivu rostlinných hormonů na délku života Caenorhabditis elegans
    Personal name Kadlecová, Alena (dissertant)
    Translated titleEffects of plant hormones on the lifespan of Caenorhabditis elegans
    Issue data2014
    Phys.des.71 pages : il., grafy, tab.
    NoteOponent Petr Džubák
    Ved. práce Jiří Voller
    Another responsib. Džubák, Petr (opponent)
    Voller, Jiří (thesis advisor)
    Another responsib. Univerzita Palackého. Katedra buněčné biologie a genetiky (degree grantor)
    Keywords Caenorhabditis elegans * aging * cytokinins * lifespan * Caenorhabditis elegans * aging * cytokinins * lifespan
    Form, Genre diplomové práce master's theses
    UDC (043)378.2
    CountryČesko
    Languageangličtina
    Document kindPUBLIKAČNÍ ČINNOST
    TitleMgr.
    Degree programNavazující
    Degree programBiologie
    Degreee disciplineMolekulární a buněčná biologie
    book

    book

    Kvalifikační práceDownloadedSizedatum zpřístupnění
    00179189-521489596.pdf44884 KB30.04.2014
    PosudekTyp posudku
    00179189-ved-448148795.pdfPosudek vedoucího
    00179189-opon-370744219.pdfPosudek oponenta
    Call numberBarcodeLocationSublocationInfo
    DP-KBB/120 (PřF-KBO)3134517872PřF-HolicePřF, Knihovna Holice - skladIn-Library Use Only

    Caenorhabditis elegans is a useful source of information about aging. As an eukaryot, it shares several crucial aging-related conservative pathways with mammals including humans. It provides a more complex picture of biological processes than cell cultures and, compared to mammal models, it is much easier and cheaper to maintain in the laboratory. This and also many other advantages make it an ideal organism to use in basic biotechnological research and also for screenings of compounds with anti-aging potential. Cytokinins, plant hormones derived from adenine, are one group of such compounds. Some of them previously delayed senescence in cell cultures and also in flies. Moreover, they were able to suppress oxidative and glycation stress in mice. They have also been used in cosmetics for several years. However, cytokinins have never been tested on C. elegans. In this thesis, 5 compounds, either natural cytokinin bases or their synthetic derivatives, along with 2 cytokinin ribosides, were tested. The results of these experiments show that cytokinins are able to prolong the lifespan of C. elegans, possibly via hormesis.Caenorhabditis elegans is a useful source of information about aging. As an eukaryot, it shares several crucial aging-related conservative pathways with mammals including humans. It provides a more complex picture of biological processes than cell cultures and, compared to mammal models, it is much easier and cheaper to maintain in the laboratory. This and also many other advantages make it an ideal organism to use in basic biotechnological research and also for screenings of compounds with anti-aging potential. Cytokinins, plant hormones derived from adenine, are one group of such compounds. Some of them previously delayed senescence in cell cultures and also in flies. Moreover, they were able to suppress oxidative and glycation stress in mice. They have also been used in cosmetics for several years. However, cytokinins have never been tested on C. elegans. In this thesis, 5 compounds, either natural cytokinin bases or their synthetic derivatives, along with 2 cytokinin ribosides, were tested. The results of these experiments show that cytokinins are able to prolong the lifespan of C. elegans, possibly via hormesis.

Number of the records: 1  

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