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Solid-Phase Synthesis and Biological Activity of 2H-Indazole 1-Oxides and Other Nitrogenous Heterocycles

  1. Title statementSolid-Phase Synthesis and Biological Activity of 2H-Indazole 1-Oxides and Other Nitrogenous Heterocycles [rukopis] / Naděžda Cankařová
    Additional Variant TitlesSolid-Phase Synthesis and Biological Activity of 2H-Indazole 1-Oxides and Other Nitrogenous Heterocycles
    Personal name Pudelová, Naděžda (dissertant)
    Issue data2011
    Phys.des.144 s. + 1
    NoteVed. práce Jan Hlaváč
    Ved. práce Viktor Krchňák
    Another responsib. Hlaváč, Jan, 1969- (consultant)
    Krchňák, Viktor (školitel)
    Another responsib. Univerzita Palackého. Katedra organické chemie (degree grantor)
    Keywords 2H-Indazole 1-oxides * a-acylamino ketones * nitrogenous heterocycles * solid phase * combinatorial chemistry * biological activity
    Form, Genre disertace dissertations
    UDC (043.3)
    CountryČesko
    Languageangličtina
    Document kindPUBLIKAČNÍ ČINNOST
    TitlePh.D.
    Degree programDoktorský
    Degree programChemie
    Degreee disciplineOrganická chemie
    book

    book

    Kvalifikační práceDownloadedSizedatum zpřístupnění
    00170274-962452380.zip165.5 MB01.09.2011
    PosudekTyp posudku
    00170274-ved-468903108.pdfPosudek vedoucího
    00170274-opon-548776582.pdfPosudek oponenta

    The presented thesis is devoted to synthesis of nitrogenous heterocycles on solid support. The first part is focused on solid-phase synthesis of combinatorial arrays of 2H-indazole 1-oxides and their fused derivatives, 3,4-dihydropyrazino[1,2-b]indazoles and their 6-oxides by using split-split methodology. The second part of the work is focused on diversity-oriented synthesis of various nitrogenous heterocycles, such as 1H-imidazoles, 1,5-dihydropyrrol-2-ones, 1H-pyrazin-2-ones, 4,5-dihydro-1,2,5-triazepin-6-ones, morpholin-3-ones, and 2H-isoquinolin-1-ones, from polymer-supported a-acylamino ketones. Chemistry of 2H-indazoles and the other heterocycles is based on different reaction outcomes derived from 2- and 4-nitrobenzenesulfonyl derivatives. Some of prepared heterocycles were submitted for evaluation of biological activity, such as cytotoxic and antimicrobial activity.

Number of the records: 1  

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