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Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439
Title statement Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439 [rukopis] / Madhusudhan Reddy Kollareddy Additional Variant Titles Identification and Characterization of Drug Resistance Mechanisms in Cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439 Personal name Kollareddy, Madhusudhan Reddy (dissertant) Translated title Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439 Issue data 2013 Note Oponent Jiří Drábek Ved. práce Marián Hajdúch Oponent Marek Svoboda Another responsib. Drábek, Jiří, 1969- (opponent) Hajdúch, Marián (školitel) Svoboda, Marek, 1975- (opponent) Another responsib. Univerzita Palackého. Ústav patologie (degree grantor) Keywords drug resistance * mechanisms * Aurora kinase inhibitors * CYC116 * ZM447439 * drug resistance * mechanisms * Aurora kinase inhibitors * CYC116 * ZM447439 Form, Genre disertace dissertations UDC (043.3) Country Česko Language čeština Document kind PUBLIKAČNÍ ČINNOST Title Ph.D. Degree program Doktorský Degree program Pediatrie Degreee discipline Pediatrie 
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Kvalifikační práce Downloaded Size datum zpřístupnění 00184758-631527812.pdf 15 21.9 MB 12.04.2013 Posudek Typ posudku 00184758-opon-284628931.pdf Posudek oponenta
This PhD thesis is focused on the identification of potential tumor cell resistance mechanisms to a novel Aurora kinase inhibitor CYC116, which has been tested in a Phase I clinical study. Alongside CYC116, we also included an experimental Aurora kinase inhibitor, ZM447439 to generate resistant HCT116 clones.This PhD thesis is focused on the identification of potential tumor cell resistance mechanisms to a novel Aurora kinase inhibitor CYC116, which has been tested in a Phase I clinical study. Alongside CYC116, we also included an experimental Aurora kinase inhibitor, ZM447439 to generate resistant HCT116 clones.
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