Number of the records: 1
Biomedical Applications of Acridines
Title statement Biomedical Applications of Acridines [electronic resource] : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases / by Jan Ježek, Jan Hlaváček, Jaroslav Šebestík. Publication Cham : Springer International Publishing : Imprint: Springer, 2017. Phys.des. XIII, 237 p. 79 illus., 25 illus. in color. online resource. ISBN 9783319639536 Edition Progress in Drug Research, ISSN 0071-786X ; 72 Contents Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook. Notes to Availability Přístup pouze pro oprávněné uživatele Another responsib. Hlaváček, Jan. Šebestík, Jaroslav. Another responsib. SpringerLink (Online service) Subj. Headings Chemistry. * Neurochemistry. * Pharmacology. * Bioorganic chemistry. * Medicinal chemistry. * Nucleic acids. * Proteins. Form, Genre elektronické knihy electronic books Country Německo Language angličtina Document kind Electronic books URL Plný text pro studenty a zaměstnance UPOL book
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Preliminary ToC 1 Introduction -- 2 Nomenclature -- 3. Syntheses -- 4. Interactions of acridines with nucleic acids -- 5. Intercations with proteins -- 6. Applications for treament of neurodegenerative diseases -- 7. Some applications of selective toxicities of acridines -- 8. Acridine on dendrimeric carriers -- 9 Acridines used for staining -- 10 Miscellaneous -- 11 Conclusions and outlook.
Number of the records: 1