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Smart external stimulus-responsive nanocarriers for drug and gene delivery
Title statement Smart external stimulus-responsive nanocarriers for drug and gene delivery / Mahdi Karimi, Parham Sahandi Zangabad, Amir Ghasemi and Michael R. Hamblin. [elektronický zdroj] Publication San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2015] Distribution Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2015] Phys.des. 1 online resource (various pagings) : illustrations (some color). ISBN 9781681742021 (online) 9781681740744 mobi Edition [IOP release 2] IOP concise physics, ISSN 2053-2571 Note "Version: 20151101"--Title page verso. "A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso. Internal Bibliographies/Indexes Note Includes bibliographical references. Contents Preface -- Acknowledgments -- Author biography -- 1. Introduction Content note 2. Light-sensitive nanocarriers -- 2.1. Introduction -- 2.2. Photo-sensitive nanoparticle-based carriers -- 2.3. Drug release via electrostatic assembly/disassembly (reversed surface charge) -- 2.4. Chromophore (or photosensitizer)-activated drug release -- 2.5. Photo-thermal-based drug release -- 2.6. Photo-sensitive caging/uncaging based on photolabile protecting groups -- 2.7. Photo-reduction-triggered drug release. 3. Temperature-sensitive nanocarriers -- 3.1. Introduction -- 3.2. LCST/UCST behavior -- 3.3. Thermo-responsive nanocarriers -- 3.4. Modulation of phase transition temperature in thermo-responsive nanoparticles -- 3.5. Sustained drug release by hydrophobic hydrogels -- 3.6. Cancer therapy via thermo-responsive nanocarriers -- 3.7. Temperature-responsive gene delivery systems -- 3.8. Thermo-sensitive co-delivery systems for cancer therapy -- 3.9. Temperature in photothermal-responsive micro/nano-systems. 4. Magnetic-responsive nanocarriers -- 4.1. Introduction -- 4.2. Magnetic-responsive particles for drug delivery -- 4.3. Magnetic-responsive particles for gene delivery. 5. Ultrasound-responsive nanocarriers -- 5.1. Introduction -- 5.2. Composition and structure of microbubbles -- 5.3. Ultrasound-responsive materials in drug delivery -- 5.4. Ultrasound-responsive materials in gene delivery. 6. Electrical and mechanical-responsive nanocarriers -- 6.1. Introduction -- 6.2. Electric field-sensitive polymers -- 6.3. Mechanical-responsive nanomaterials -- 7. Nanotoxicology and future scope for smart nanoparticles. Notes to Availability Přístup pouze pro oprávněné uživatele Audience Biomedical engineers. Note Způsob přístupu: World Wide Web.. Požadavky na systém: Adobe Acrobat Reader. Another responsib. Zangabad, Parham Sahandi, Ghasemi, Amir, Hamblin, Michael R., Another responsib. Morgan & Claypool Publishers, Institute of Physics (Great Britain), Subj. Headings Nanomedicine. * Drug delivery systems. * Gene therapy. * TECHNOLOGY & ENGINEERING / Biomedical. * Biomedical Engineering. MeSH Nanomedicine - methods. * Drug Delivery Systems. * Drug Therapy - methods. * Gene Therapy - methods. * Nanostructures - therapeutic use. Form, Genre elektronické knihy electronic books Country Kalifornie Language angličtina Document kind Electronic books URL Plný text pro studenty a zaměstnance UPOL 
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The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.
Preface -- Acknowledgments -- Author biography -- 1. Introduction2. Light-sensitive nanocarriers -- 2.1. Introduction -- 2.2. Photo-sensitive nanoparticle-based carriers -- 2.3. Drug release via electrostatic assembly/disassembly (reversed surface charge) -- 2.4. Chromophore (or photosensitizer)-activated drug release -- 2.5. Photo-thermal-based drug release -- 2.6. Photo-sensitive caging/uncaging based on photolabile protecting groups -- 2.7. Photo-reduction-triggered drug release3. Temperature-sensitive nanocarriers -- 3.1. Introduction -- 3.2. LCST/UCST behavior -- 3.3. Thermo-responsive nanocarriers -- 3.4. Modulation of phase transition temperature in thermo-responsive nanoparticles -- 3.5. Sustained drug release by hydrophobic hydrogels -- 3.6. Cancer therapy via thermo-responsive nanocarriers -- 3.7. Temperature-responsive gene delivery systems -- 3.8. Thermo-sensitive co-delivery systems for cancer therapy -- 3.9. Temperature in photothermal-responsive micro/nano-systems4. Magnetic-responsive nanocarriers -- 4.1. Introduction -- 4.2. Magnetic-responsive particles for drug delivery -- 4.3. Magnetic-responsive particles for gene delivery5. Ultrasound-responsive nanocarriers -- 5.1. Introduction -- 5.2. Composition and structure of microbubbles -- 5.3. Ultrasound-responsive materials in drug delivery -- 5.4. Ultrasound-responsive materials in gene delivery6. Electrical and mechanical-responsive nanocarriers -- 6.1. Introduction -- 6.2. Electric field-sensitive polymers -- 6.3. Mechanical-responsive nanomaterials -- 7. Nanotoxicology and future scope for smart nanoparticles.
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