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Effects of plant hormones on the lifespan of Caenorhabditis elegans
Title statement Effects of plant hormones on the lifespan of Caenorhabditis elegans [rukopis] / Alena Kadlecová Additional Variant Titles Studium vlivu rostlinných hormonů na délku života Caenorhabditis elegans Personal name Kadlecová, Alena (dissertant) Translated title Effects of plant hormones on the lifespan of Caenorhabditis elegans Issue data 2014 Phys.des. 71 pages : il., grafy, tab. Note Oponent Petr Džubák Ved. práce Jiří Voller Another responsib. Džubák, Petr (opponent) Voller, Jiří (thesis advisor) Another responsib. Univerzita Palackého. Katedra buněčné biologie a genetiky (degree grantor) Keywords Caenorhabditis elegans * aging * cytokinins * lifespan * Caenorhabditis elegans * aging * cytokinins * lifespan Form, Genre diplomové práce master's theses UDC (043)378.2 Country Česko Language angličtina Document kind PUBLIKAČNÍ ČINNOST Title Mgr. Degree program Navazující Degree program Biologie Degreee discipline Molekulární a buněčná biologie book
Kvalifikační práce Downloaded Size datum zpřístupnění 00179189-521489596.pdf 47 884 KB 30.04.2014 Posudek Typ posudku 00179189-ved-448148795.pdf Posudek vedoucího 00179189-opon-370744219.pdf Posudek oponenta Call number Barcode Location Sublocation Info DP-KBB/120 (PřF-KBO) 3134517872 PřF-Holice PřF, Knihovna Holice - sklad In-Library Use Only
Caenorhabditis elegans is a useful source of information about aging. As an eukaryot, it shares several crucial aging-related conservative pathways with mammals including humans. It provides a more complex picture of biological processes than cell cultures and, compared to mammal models, it is much easier and cheaper to maintain in the laboratory. This and also many other advantages make it an ideal organism to use in basic biotechnological research and also for screenings of compounds with anti-aging potential. Cytokinins, plant hormones derived from adenine, are one group of such compounds. Some of them previously delayed senescence in cell cultures and also in flies. Moreover, they were able to suppress oxidative and glycation stress in mice. They have also been used in cosmetics for several years. However, cytokinins have never been tested on C. elegans. In this thesis, 5 compounds, either natural cytokinin bases or their synthetic derivatives, along with 2 cytokinin ribosides, were tested. The results of these experiments show that cytokinins are able to prolong the lifespan of C. elegans, possibly via hormesis.Caenorhabditis elegans is a useful source of information about aging. As an eukaryot, it shares several crucial aging-related conservative pathways with mammals including humans. It provides a more complex picture of biological processes than cell cultures and, compared to mammal models, it is much easier and cheaper to maintain in the laboratory. This and also many other advantages make it an ideal organism to use in basic biotechnological research and also for screenings of compounds with anti-aging potential. Cytokinins, plant hormones derived from adenine, are one group of such compounds. Some of them previously delayed senescence in cell cultures and also in flies. Moreover, they were able to suppress oxidative and glycation stress in mice. They have also been used in cosmetics for several years. However, cytokinins have never been tested on C. elegans. In this thesis, 5 compounds, either natural cytokinin bases or their synthetic derivatives, along with 2 cytokinin ribosides, were tested. The results of these experiments show that cytokinins are able to prolong the lifespan of C. elegans, possibly via hormesis.
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