Number of the records: 1

properdin

Topical term	properdin
See link	Complement Factor P (UF)
See also	beta-globuliny
	komplement
	imunologické faktory (PA)
Linking entry	Properdin
Conspect	D12. - 776. - 124. - 486. - 274. - 965
	D12. - 776. - 124. - 790. - 223. - 624
	D12. - 776. - 377. - 715. - 182. - 624
Note	A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
Database	MESH
References	(2) - MESH

subject heading

Number of the records: 1