Pudelová, Naděžda
Solid-Phase Synthesis and Biological Activity of 2H-Indazole 1-Oxides and Other Nitrogenous Heterocycles [rukopis] / Naděžda Cankařová. -- 2011. -- 144 s. + 1. -- Ved. práce Jan Hlaváč. -- Ved. práce Viktor Krchňák. -- Abstrakt: The presented thesis is devoted to synthesis of nitrogenous heterocycles on solid support. The first part is focused on solid-phase synthesis of combinatorial arrays of 2H-indazole 1-oxides and their fused derivatives, 3,4-dihydropyrazino[1,2-b]indazoles and their 6-oxides by using split-split methodology. The second part of the work is focused on diversity-oriented synthesis of various nitrogenous heterocycles, such as 1H-imidazoles, 1,5-dihydropyrrol-2-ones, 1H-pyrazin-2-ones, 4,5-dihydro-1,2,5-triazepin-6-ones, morpholin-3-ones, and 2H-isoquinolin-1-ones, from polymer-supported a-acylamino ketones. Chemistry of 2H-indazoles and the other heterocycles is based on different reaction outcomes derived from 2- and 4-nitrobenzenesulfonyl derivatives. Some of prepared heterocycles were submitted for evaluation of biological activity, such as cytotoxic and antimicrobial activity.
Hlaváč, Jan, 1969-. Krchňák, Viktor. Univerzita Palackého. Katedra organické chemie
2H-Indazole 1-oxides. a-acylamino ketones. nitrogenous heterocycles. solid phase. combinatorial chemistry. biological activity. disertace
(043.3)