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botulotoxiny
SYS d001905 LBL 02494nz--a2200409n--4500 003 CZ-PrNML 005 20240206162307.5 008 990101-n-ancnnbaba----------||-ana-----d 035 $a (DNLM)D001905 040 $a ABA008 $b cze $f czmesh 072 $a D08. $x 811. $x 277. $x 656. $x 300. $x 480. $x 153 072 $a D08. $x 811. $x 277. $x 656. $x 675. $x 374. $x 153 072 $a D12. $x 776. $x 097. $x 156 072 $a D23. $x 946. $x 123. $x 179 150 $a botulotoxiny $2 czmesh 450 $w i $a botulin $i UF 450 $w i $a Botulin $i UF 450 $w i $a Botulinum Neurotoxin $i UF 450 $w i $a Botulinum Neurotoxins $i UF 450 $w i $a Botulinum Toxin $i UF 450 $w i $a Clostridium botulinum Toxins $i UF 450 $w i $a jed klobásový $i UF 450 $w i $a klobásový jed $i UF 550 $w g $a bakteriální proteiny $7 upol_us_auth*d001426 550 $w g $a bakteriální toxiny $7 upol_us_auth*d001427 550 $w g $a metaloendopeptidasy $7 upol_us_auth*d008666 550 $w h $a botulotoxiny typ A $7 upol_us_auth*d019274 550 $w i $a botulismus $i RT $7 upol_us_auth*d001906 550 $w i $a inhibitory uvolňování acetylcholinu $i PA $7 upol_us_auth*d065087 550 $w i $a neurotoxiny $i PA $7 upol_us_auth*d009498 667 $a /antag permitted but consider also BOTULINUM ANTITOXIN 680 $i Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. 688 $a 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71) 750 -2
$a Botulinum Toxins $2 czmesh 980 $x M 982 $a 1
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