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NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING
Údaje o názvu NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING [rukopis] / Zsófia Turi Další variantní názvy NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING Osobní jméno Turi, Zsófia, (autor diplomové práce nebo disertace) Překl.náz NOVEL ROLE OF HEATR1 IN RIBOSOME BIOGENESIS AND DNA DAMAGE SIGNALING Vyd.údaje 2019 Poznámka Oponent Jan Bouchal Ved. práce Pavel Moudrý Oponent Pavla Vašicová Dal.odpovědnost Bouchal, Jan (oponent) Moudrý, Pavel, (školitel) Vašicová, Pavla, (oponent) Dal.odpovědnost Univerzita Palackého. Doktorské studijní programy LF (udelovatel akademické hodnosti) Klíč.slova Ribosome biogenesis * nucleolus * HEATR1 * p53 * cancer * DNA damage response * Ribosome biogenesis * nucleolus * HEATR1 * p53 * cancer * DNA damage response Forma, žánr disertace dissertations MDT (043.3) Země vyd. Česko Jazyk dok. čeština Druh dok. PUBLIKAČNÍ ČINNOST Titul Ph.D. Studijní program Doktorský Studijní program Pediatrie Studijní obor Pediatrie kniha
Kvalifikační práce Staženo Velikost datum zpřístupnění 00263220-745516278.pdf 38 14.3 MB 30.04.2019 Posudek Typ posudku 00263220-opon-677998166.pdf Posudek oponenta Průběh obhajoby datum zadání datum odevzdání datum obhajoby přidělená hodnocení typ hodnocení 00263220-prubeh-803132754.pdf 28.08.2014 30.04.2019 26.11.2019 S 2
In this work, we identified a nucleolar protein, HEATR1 as an important player of ribosome biogenesis. In the absence of this protein, ribosome biogenesis stress is activated, characterized by the elevated level of p53, cell cycle arrest and structural changes of the nucleolus. Furthermore, HEATR1 seems to be involved in the early steps of ribosome biogenesis, since it possesses similar localization signal to Pol I and its ablation completely abolishes rRNA transcription. Besides its function in ribosome biosynthesis, HEATR1 may be required for DNA damage signaling as well, evidenced by DNA damage-dependent phosphorylation of this protein. Overall, our work presents HEATR1, a novel player in ribosome biogenesis and DNA damage response.In this work, we identified a nucleolar protein, HEATR1 as an important player of ribosome biogenesis. In the absence of this protein, ribosome biogenesis stress is activated, characterized by the elevated level of p53, cell cycle arrest and structural changes of the nucleolus. Furthermore, HEATR1 seems to be involved in the early steps of ribosome biogenesis, since it possesses similar localization signal to Pol I and its ablation completely abolishes rRNA transcription. Besides its function in ribosome biosynthesis, HEATR1 may be required for DNA damage signaling as well, evidenced by DNA damage-dependent phosphorylation of this protein. Overall, our work presents HEATR1, a novel player in ribosome biogenesis and DNA damage response.
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