Počet záznamů: 1
Molecular drug properties
Údaje o názvu Molecular drug properties : measurement and prediction / edited by Raimund Mannhold Nakladatel Weinheim : Wiley-VCH, [2008] Copyright ©2008 Fyz.popis 1 online zdroj (xxx, 471 stran) : ilustrace (některé barevně) ISBN 3527621296 (online ; pdf) 9783527621293 128201059X 9781282010598 Edice Methods and principles in medicinal chemistry ; vol. 37 Poznámky o skryté bibliografii a rejstřících Obsahuje bibliografické odkazy a rejstřík Poznámka o obsahu 9 Conformational Analysis of Drugs by Nuclear Magnetic Resonance SpectroscopyPart IV Solubility; 10 Drug Solubility in Water and Dimethylsulfoxide; 11 Challenge of Drug Solubility Prediction; Part V Lipophilicity; 12 Lipophilicity: Chemical Nature and Biological Relevance; 13 Chromatographic Approaches for Measuring Log P; 14 Prediction of Log P with Substructure-based Methods; 15 Prediction of Log P with Property-based Methods; 16 The Good, the Bad and the Ugly of Distribution Coefficients: Current Status, Views and Outlook; Part VI Drug- and Lead-likeness.. 17 Properties Guiding Drug- and Lead-likenessIndex. Poznámky k dostupnosti Přístup pouze pro oprávněné uživatele Poznámky Způsob přístupu: World Wide Web Defekty eBooks on EBSCOhost Dal.odpovědnost Mannhold, Raimund (editor) Předmět.hesla farmaceutická biochemie pharmaceutical biochemistry * léčivé přípravky pharmaceutical preparations Forma, žánr elektronické knihy electronic books Konspekt 615 - Farmacie. Farmakologie MDT 615.45 , 615:577.1 , (0.034.2:08) Země vyd. Německo Jazyk dok. angličtina Druh dok. Elektronické zdroje URL http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=259438 
kniha
This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity, solubility, electronic properties and conformation.
9 Conformational Analysis of Drugs by Nuclear Magnetic Resonance SpectroscopyPart IV Solubility; 10 Drug Solubility in Water and Dimethylsulfoxide; 11 Challenge of Drug Solubility Prediction; Part V Lipophilicity; 12 Lipophilicity: Chemical Nature and Biological Relevance; 13 Chromatographic Approaches for Measuring Log P; 14 Prediction of Log P with Substructure-based Methods; 15 Prediction of Log P with Property-based Methods; 16 The Good, the Bad and the Ugly of Distribution Coefficients: Current Status, Views and Outlook; Part VI Drug- and Lead-likeness.17 Properties Guiding Drug- and Lead-likenessIndex.
Počet záznamů: 1