Historical perspectives. Anti-inflammatory drugs in the 21st century / K.D. Rainsford -- Inflammatory mechanisms of pathogenesis. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair / J. Brice Weinberg, Beverley Fermor, Farshid Guilak -- Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ / Paolo Calabro', Edward T.H. Yeh -- Cyclooxygenase-2 (COX-2) and the inflammogenesis of cancer / Randall E. Harris -- Role of COX-2 in inflammatory and degenerative brain diseases / Luisa Minghetti -- Inflammation and Cardiovascular Disease: the Coxib Controversy. Cardiovascular effects of the selective cyclooxygenase-2 inhibitors / William B. White -- COX-2 inhibitors and Cardiovascular Risk / Daniel J. Salzberg, Matthew R. Weir -- A biological rationale for cardiotoxic effects of rofecoxib: comparative analysis with other COX-2 selective agents and NSAIDs / R. Preston Mason [and others] -- COX-2 Blockade in cancer prevention and therapy. Cancer chemoprevention by COX-2 blockade: results of case control studies / Randall E. Harris, Joanne Beebe-Donk, Galal A. Alshafie -- Strategies for colon cancer prevention: combination of chemopreventive agents / Bandaru S. Reddy -- Inflammation and neurodegenerative disease. NSAIDs for the chemoprevention of Alzheimer's disease / Christine A. Szekely, Terrence Town, Peter P. Zandi -- Inflammation in Parkinson's disease: causative or epiphenomenal? / Andreas Hald, Johan van Beek, and Julie Lotharius -- Nutrition, inflammation and chronic disease. Essential polyunsaturated fatty acids, inflammation, atherosclerosis and cardiovascular dieseases / Michel de Logeril -- Nutritional interventiion in brain aging: reducing the effects of inflaammation and oxidative stress / Frances C. Lau, Barbara Shukitt-Hale, James Joseph.