Úvod: Deregulácia rozličných členov rodiny TGF (transformujúci rastový faktor beta) je spojená s asthmou bronchiale (AB) a chronickou obstrukčnou chorobou pľúc (CHOCHP). Avšak jeden člen tejto rodiny býva vynechaný zo štúdií. Cieľom tejto štúdie bolo stanoviť expresiu TGF2 v bronchoalveolárnej (BAL) laváži. Metódy: Kvantitatívna PCR metóda bola použitá na posúdenie relatívnej expresie TGF2 u 13 CHOCHP pacientov, 14 AB pacientov a 22 pacientov v kontrolnej skupine. Výsledky: Expresia TGF2 v BAL bola zvýšená u pacientov s CHOCHP (p = 0.01) v porovnaní s kontrolnou skupinou. Medzi pacientmi s AB a kontrolnou skupinou nebol zistený rozdiel (p > 0.5). Taktiež nebol zistený rozdiel v expresii TGF2 medzi pacientmi s CHOCHP a AB (p > 0.5). Záver: Táto štúdia rozširuje súčasné znalosti o TGF rodine. Naše pozorovania by však mali byť potvrdené na nezávislej skupine pacientov a taktiež by mali byť možné rozdiely v expresii TGF2 u odlišných fenotypov CHOCHP preskúmané ďalšími štúdiami.Background and objective: Dysregulation of various members of the TGF (transforming growth factor beta) family has been associated with asthma bronchiale (AB) and chronic obstructive pulmonary disease (COPD). However, one member of this family is omitted in clinical studies. The objective of this study was to investigate the expression of TGF2 in bronchoalveolar (BAL) lavage. Methods: Quantitative PCR method was used to assess the relative expression of TGF2 in 13 COPD patients, 14 AB patients and 22 control patients. Results: BAL expression of TGF2 was increased in COPD patients (p = 0.01) compared with control patients. There was no difference (p > 0.5) between AB and control patients. Further relative expression of TGF2 was similar between COPD and AB patients (p > 0.5). Conclusion: This study extends current knowledge of the TGF family. However, our main observations on TGF2 should be confirmed in an independent cohort of patients and the possible differences among COPD phenotypes should also be investigated by other studies.