Diabetes in its Historical and Social Context. The History of Diabetes Mellitus / Robert B Tattersall -- Classification and Diagnosis of Diabetes / Ambady Ramachandran, Chamukuttan Snehalatha, Arun Nanditha -- Epidemiology of Type 1 Diabetes / Lars C Stene, Jaakko Tuomilehto -- Epidemiology of Type 2 Diabetes / Ronald CW Ma, Peter CY Tong -- The Global Burden of Diabetes / Mohammed K Ali, Karla I Galaviz, Mary Beth Weber, KM Venkat Narayan -- Normal Physiology. Islet Function and Insulin Secretion / Peter M Jones, Shanta J Persaud -- Glucagon in Islet and Metabolic Regulation / Darleen Sandoval, Jenny Tong, David D' Alessio -- Mechanism of Insulin Action / Morris F White -- Control of Weight: How Do We Get Fat? / Arianne N Sweeting, Ian D Caterson -- Pathogenesis of Diabetes. Autoimmune Type 1 Diabetes / Shehab Alshiekh, Helena Elding Larsson, Sten-A Ivarsson, Ake Lernmark -- Other Disorders with Type 1 Phenotype / Alice PS Kong, Elaine YK Chow, Juliana CN Chan -- Abnormalities of Insulin Secretion and [beta]-Cell Defects in Type 2 Diabetes / Stefano Del Prato, Cristina Bianchi, Giuseppe Daniele -- Insulin Resistance in Type 2 Diabetes / Michael Roden, Kitt Petersen, Gerald Shulman -- Genetic Architecture of Type 2 Diabetes / Rashmi B Prasad, Leif Groop -- Metabolic Disturbances in Diabetes / Adrian Vella, Robert A Rizza -- Obesity and Diabetes / Hans Hauner -- The Microbiome and Diabetes / Amanda J Cox, Nicholas P West, Allan W Cripps -- Other Types of Diabetes. Monogenic Causes of Diabetes / Shivani Misra, Andrew T Hattersley -- Drug-Induced Diabetes / Charles D Ponte, Devra K Dang -- Endocrine Disorders that Cause Diabetes / Rachel E Jennings, Neil A Hanley -- Pancreatic Diseases and Diabetes / Ranjit Unnikrishnan, Viswanathan Mohan -- Managing the Patient with Diabetes. Clinical Presentations of Diabetes / Ee Lin Lim, Roy Taylor -- The Aims of Diabetes Care / Katharine D Barnard, Richard IG Holt -- Educating the Person with Diabetes / Ingrid Willaing, Michael Vallis -- Lifestyle Issues: Diet / Nicola Guess -- Lifestyle Issues: Exercise / Mimi Z Chen, Robert C Andrews -- Monitoring Diabetes / Andrew Farmer -- Drug Therapy: Special Considerations in Diabetes / Bernard MY Cheung, Ronald CW Ma -- Treatment of Diabetes. Insulin and Insulin Treatment / Stephen Gough, Parth Narendran -- New Technologies for Glucose Monitoring and Insulin Administration / David L Horwitz, David C Klonoff -- Oral Glucose-Lowering Agents / Clifford J Bailey, Andrew J Krentz -- Non-Insulin Parenteral Therapies / Tina Vilsbøll, Mikkel Christensen, Tina Jorsal, Filip K Knop -- How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies / Silvio E Inzucchi, David R Matthews -- In-Hospital Treatment and Surgery in People with Diabetes / Ketan Dhatariya, June James -- Hypoglycemia in Diabetes / Philip E Cryer, Ana María Arbeláez -- Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State / Niels Møller -- Microvascular Complications in Diabetes. Pathogenesis of Microvascular Complications / Allan Flyvbjerg -- Diabetic Retinopathy / Toke Bek -- Diabetic Nephropathy / Sally M Marshall, Allan Flyvbjerg -- Diabetic Peripheral and Autonomic Neuropathy / Dan Ziegler -- Macrovascular Complications in Diabetes. Pathogenesis of Macrovascular Complications in Diabetes / Stephen P Gray, Elyse Di Marco, Riccardo Candido, Mark E Cooper, Karin AM Jandeleit-Dahm -- Cardiovascular Risk Factors: Hypertension / Peter M Nilsson -- Diabetic Dyslipidemia and Risk of Cardiovascular Disease / Adie Viljoen, Supriya Joshi, Anthony S Wierzbicki -- Ischemic Heart Disease in Diabetes / Christoph H Saely, Kourosh Vathie, Heinz Drexel -- Congestive Heart Failure / Anna Norhammar, Isabelle Johansson, Inga S Thrainsdottir, Lars Rydén -- Cerebrovascular Disease / Colum F Amory, Jesse Weinberger -- Peripheral Vascular Disease / Henrik H Sillesen -- Other Complications of Diabetes. Foot Problems in People with Diabetes / Andrew JM Boulton -- Sexual Function in Men and Women with Diabetes / David Price -- Gastrointestinal Manifestations of Diabetes / Adil E Bharucha, Michael Camilleri -- Diabetes and Non-Alcoholic Fatty Liver Disease / Shivakumar Chitturi, Geoffrey C Farrell -- The Skin in Diabetes / Graham R Sharpe, Paul D Yesudian -- Bone and Rheumatic Disorders in Diabetes / Andrew Grey, Nicola Dalbeth -- Diabetes and Cancer: Evidence for Risk, Methodology and Implications / Ellena Badrick, Andrew G Renehan -- Diabetes and Infections / Clive S Cockram, Bonnie CK Wong -- Psychosocial Aspects of Diabetes. Psychological Factors and Diabetes Mellitus / Frans Pouwer, Jane Speight -- Psychiatric Disorders and Diabetes / Richard IG Holt, Leslie Citrome -- Social Aspects of Diabetes / Brian M Frier, Mark WJ Strachan -- Diabetes in Special Groups. Diabetes in Childhood / Shideh Majidi, Christine M Chan, Marian Rewers -- Adolescence and Emerging Adulthood: Diabetes in Transition / Rebecca K Snelgrove, Dayna E McGill, Lori MB Laffel -- Diabetes in Pregnancy / Tim Cundy -- Diabetes in Old Age / Ahmed H Abdelhafiz, Alan J Sinclair -- Diabetes at the End of Life / June James, Jean MacLeod, Robert Gregory -- Delivery and Organization of Diabetes Care. The Role of the Multidisciplinary Team Across Primary and Secondary Care / Samuel I Seidu, Kamlesh Khunti, Melanie J Davies -- Models of Diabetes Care Across Different Resource Settings / Naomi S Levitt, Sam Surka, Andrew Farmer, Bob Mash -- Future Directions. Future Drug Treatments for Type 1 Diabetes / Jennifer L Sherr, Eda Cengiz, Michelle A Van Name, Stuart A Weinzimer, William V Tamborlane -- Future Drug Treatments for Type 2 Diabetes / Clifford J Bailey -- Stem Cell Therapy in Diabetes / Angelo Avogaro, Gian Paolo Fadini -- Islet Transplantation / Angela Koh, Peter E Senior, AM James Shapiro -- Gene Therapy for Diabetes / Virginia Haurigot, Veronica Jimenez, Fatima Bosch -- Future Models of Diabetes Care / Sanjeev N Mehta, Robert A Gabbay.