This book gathers the carefully reviewed proceedings of the 19th International Conference on Systems Science, presenting recent research findings in the areas of Artificial Intelligence, Machine Learning, Communication/Networking and Information Technology, Control Theory, Decision Support, Image Processing and Computer Vision, Optimization Techniques, Pattern Recognition, Robotics, Service Science, Web-based Services, Uncertain Systems and Transportation Systems. The International Conference on Systems Science was held in Wroclaw, Poland from September 7 to 9, 2016, and addressed a range of topics, including systems theory, control theory, machine learning, artificial intelligence, signal processing, communication and information technologies, transportation systems, multi-robotic systems and uncertain systems, as well as their applications. The aim of the conference is to provide a platform for communication between young and established researchers and practitioners, fostering future joint research in systems science.