History of charged particle radiotherapy / Herman D. Suit and William Chu -- Radiobiology of charged particles / Leo Gerweck and Harold Paganetti -- Facility design / Edward T.M. Tsoi and Jay Flanz -- Particle accelerators / Jay Flanz -- Treatment delivery systems: passive beam scattering / Bernard Gottschalk -- Treatment delivery systems: pencil beam scattering / Eros Pedroni -- Quality assurance / Richard L. Maughan and Jonathan B. Farr -- Patient positioning and set-up verification for planning and treatment / Martijn Engelsman, Alejandro Mazal, and David A. Jaffray -- Treatment planning: principles and systems/optimization / Hanne M. Kooy ... [et al.] -- Treatment planning: passive scattering / Hanne M. Kooy and Judy A. Adams --Treatment planning: intensity modulated proton therapy / Antony John Lomax -- Clinical issues in proton radiotherapy / Thomas F. DeLaney --Overview of experience with heavier charged particle radiotherapy / Hirohiko Tsujii, Tadashi Kamada, and Juergen Debus -- Pediatric tumors / Torunn Yock ... [et al.] -- Central nervous system / Helen A. Shih ... [et al.] -- Eye / Evangelos S. Gragoudas ... [et al.] -- Skull base and cervical spine / Eugen B. Hug and John E. Munzenrider -- Bone and soft tissue / Thomas F. DeLaney and David G. Kirsch -- Head and neck: paranasal sinus and nasal cavity / Pascal Pommier ... [et al.] -- Head and neck: nasopharynx / Samir Patel, Judy A. Adams, and Annie W. Chan -- Head and neck: oropharynx, oral cavity, and salivary glands / Jerry D. Slater and Ryan S. Grover -- Prostate / Anthony L. Zietman ... [et al.] -- Lung / David A. Bush -- Gastrointestinal / Koichi Tokuuye ... [et al.] -- Gynecologic / Takashi Nakano ... [et al.] -- Breast / Shannon M. MacDonald and Alphonse Taghian -- Lymphoma / Nancy Price Mendenhall and Daniel Yeung.